Reciprocal Crosses in Mice II. An Introduction to Results of Four
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چکیده
This report is to serve as an introduction to hy bridization studies which have been undertaken concerning adrenal cortical tumors and related pathological conditions. It is planned that reports similar to that for the reciprocal DBA and CE hy brids (27) will also be made. Hybridization studies have been used in many types of experiments with animals and with plants. Such experiments were of the type Mendel used and on which he based his principles of unit inher itance. Hybridization experiments with animals can be used not only to determine chromosomal in heritance, but also for purposes of evaluating other types of influences on the offspring, e.g., maternal influence influential in breast tumor occurrence in mice. The effects of gonadectomy on certain inbred strains of mice have already been reported in de tail (9, 10, 19, 23, 28—36),as well as some intensive studies on the pituitary (3, 5, 26) and the uterus (2) of some F1 reciprocal crosses. Recently, the findings on the reciprocal cross of strains DBA and CE have been reported (27). With this as a pat tern, it is possible to indicate how the other recip rocal crosses thus far investigated compare with this series. Primarily, the entire series was undertaken to determine the effect of inheritance on the response of the adrenals of the F1 animals to gonadectomy. However, certain other factors could not be neg lected and have been included in the results. A
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تاریخ انتشار 2006